Online Training: Genetic Toxicology within the Framework of the Plant Protection Regulation

This training is aiming to give you the basic knowledge on genetic toxicology within the framework of Regulation 1107/2009, with an overview of assay conduct, data generation and evaluation. This will be delivered virtually in a compact format of an intensive morning and afternoon session with the opportunity to ask and discuss your questions.

Programme: 

9:30 | Welcome address by the organisers and introduction by the trainer

Overview of genotoxic damage and data generation

• Types of DNA damage and an overview of DNA repair
• Overview of the regulatory approved genotoxicity tests available across regulatory frameworks (REACH, BPR, PPP, Cosmetics, Food/Feed)
• Relevance of historical control data to aid assay acceptability and data interpretation

Relevance of historical control data to aid assay acceptability and data interpretation

• Bacterial (reverse) gene mutation assay overview and data interpretation
• Mammalian (forward [tk / hprt]) gene mutation assay overview and data interpretation

In vitro mammalian structural and numerical chromosomal damage, data generation and evaluation

• Mammalian micronucleus assay overview and data interpretation
• Why the mammalian chromosomal aberration assay does not address aneugenicity

In vivo mammalian genotoxicity follow-on approaches

• Rodent bone marrow micronucleus assay overview and data interpretation
• Rodent comet and transgenic assay overview and data interpretation, and which one to use.

Questions and answers

14:45 | End of the online training

Learning Outcomes:

• Learn all about regulatory approved genotoxicity tests
• Learn the relevance of historical control data
• Learn different types of DNA damage and get an overview on DNA repair
• Learn about gene mutation and chromosomal damage, data generation and evaluation
• Learn how to use in vivo mammalian genotoxicity follow-on approaches

Who should attend this training?

Professionals working in the fields of:

• Toxicology
• Ecotoxicology
• Exposure assessment
• Risk assessment
• Registration
• Regulatory & government affairs
• Monitoring & computer modelling

Sectors that should take part:

• Agrochemical industry
• Professional associations
• Consultancies