Clinical Kidney, Pancreas and Islet Transplantation

About this course: Kidney transplantation is a major advance of modern medicine which provides high-quality of life for patients with end-stage renal disease. What used to be an experimental, risky, and very limited treatment option more than 50 years ago is now routinely performed in many countries worldwide. The number of renal transplants is expected to rise sharply in the next decade since the proportion of patients with end stage renal disease is increasing. Are you interested in clinical kidney, pancreas and islet transplantation? If you are a (bio) medical student or a health care professional who works in the (pre) clinical transplant field this might be the course for you. This course is also for anyone interested in the research and knowledge on clinical transplantation. The course will be taught by a multidisciplinary team of transplant professionals and will give you the state of the art updates. It is divided in 4 modules: 1) Before the transplant 2) The surgical procedures and the challenged patient, including the patient with diabetes 3) Early challenges 4) Late challenges after transplantation. The offered modules will include lectures, interactive patient cases, 3D movies, interviews with well-known experts and with patients and a donor, a serious game to increase knowledge of the field and of course an active forum. Become an expert and join us! The course is endorsed by The European Society of Organ Transplantation (ESOT), The International Society of Nephrology (ISN) and The Transplantation Society (TTS).

Who is this class for: Anyone with a general interest in Clinical Kidney Transplantation, both beginners and professionals. This course is free, and will remain free for participants. You can purchase a certificate.

Created by:  Universiteit Leiden, Leiden University Medical Center

• Taught by:  Marlies Reinders, Dr.

  LUMC, Department of Nephrology and Transplantation

• Taught by:  Frans Claas, Professor

  LUMC, Department of Immunohaematology and Blood Transfusion

• Taught by:  Cees van Kooten , Professor

  LUMC, Department of Nephrology and Transplantation

• Taught by:  Sebastiaan Heidt, Dr.

  LUMC, Department of Immunohaematology and Blood Transfusion

• Taught by:  Volkert Huurman, Dr.

  LUMC, Department of Transplant Surgery

• Taught by:  Hans de Fijter, Professor

  LUMC, Department of Nephrology and Transplantation

• Taught by:  Eelco de Koning , Professor

  LUMC, Department of Nephrology and Transplantation and Endocrinology and Metabolism

• Taught by:  Andre Baranski, Dr.

  LUMC, Department of Transplant Surgery

• Taught by:  Ton Rabelink, Professor

  LUMC, Department of Nephrology and Transplantation

• Taught by:  Aiko de Vries, Dr.

  LUMC, Department of Nephrology and Transplantation

• Taught by:  Jan Nico Bouwes Bavinck, Dr.

  LUMC, Department of Dermatology

• Taught by:  Leo Visser , Professor

  LUMC, Department of Infectious Diseases

• Taught by:  Ingeborg Bajema, Dr.

  LUMC, Department of Pathology

Level Intermediate Commitment 4 weeks of study, 4-6 hours a week Language English How To Pass Pass all graded assignments to complete the course. User Ratings 4.7 stars Average User Rating 4.7See what learners said Coursework

Each course is like an interactive textbook, featuring pre-recorded videos, quizzes and projects.

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Universiteit Leiden Leiden University is one of Europe's foremost research universities. This prominent position gives our graduates a leading edge in applying for academic posts and for functions outside academia. Leiden University is the oldest university in the Netherlands. It was founded in February 1575, as a gift from William of Orange to the citizens of Leiden after they had withstood a long siege by the Spanish. Our motto is: Praesidium Libertatis — Bastion of Liberty. Leiden University Medical Center

Syllabus


WEEK 1


Welcome to the course



Great that you are joining us! In this course you will learn about clinical kidney, pancreas and islet transplantation and its challenges. Before you start with studying we invite you first go through our introduction module and introduce yourself in the forum to meet your fellow learners. If you encounter any difficulties while studying, please let us know in the forum. For technical difficulties or questions regarding the course certificate, you can always contact the Coursera Learner Helpdesk. Good luck & we hope you enjoy studying in this course!


1 video, 5 readings expand

1. Video: Trailer Clinical Kidney Transplantation
2. Reading: About us: Introduction to the Team
3. Reading: Welcome to Leiden University
4. Reading: Tips for studying online
5. Reading: Being successful in an international virtual learning environment
6. Reading: Behaving in an academic way
7. Discussion Prompt: Introduce yourself

Before the Transplant



Welcome to this first module of the course! We will answer important questions before transplantation. These include: why is transplantation the preferred option for patients with end stage renal disease? What are the immunological barriers for transplantation? And what are the selection criteria before transplantation? Unique 3D movies about the different immunological tests will help you to understand the concepts. There are also optional lectures, including a fascinating movie about the Eurotransplant allocation system and patient/donor interviews. At the end of the module we will link the contents you have learned to clinical patient cases, patient - donor interviews and a quiz. You can find each other on the discussion forum. With the e-tivities you can apply your knowledge. In the honors lessons more in depth immunological testing and pre transplant screening can be obtained. The lesson also includes peer reviews about important preclinical questions. Have fun and good luck with the first module!


11 videos, 4 readings expand

1. Video: Short Introduction
2. Video: The Kidney in Health and Disease
3. Video: Options if Kidneys Fail
4. Video: Immunogenetics
5. Video: Introduction to the Immune System
6. Video: The Humoral Immune System
7. Video: Histocompatibility
8. Discussion Prompt: E-tivity: Which Donor do you choose?
9. Video: Cases from Daily Practice - Patient Selection
10. Video: Eurotransplant Company Film ' than a Match'
11. Video: Interview: Transplant Recipient and Donor: Part 1
12. Reading: Glossary
13. Reading: References
14. Video: Epitopes
15. Reading: HLA Epitope Matching is the Future
16. Reading: HLA Antibody Detection: Not All Antibodies are the Same
17. Discussion Prompt: E-tivity: Which Strategy would you choose for this Highly Sensitized Patient?

Graded: Check your knowledge
Graded: Advise your Colleague: a Pretransplantation Question
Graded: Check your knowledge

WEEK 2


The Procedure and the Patient



Now you know the factors of importance before transplantation, including the immunological barriers and important aspects for patient selection, we can focus on challenged patient groups and on surgical procedures. What does a kidney, pancreas and islet transplantation surgical procedure look like? What is important? And what are the key aspects in elderly patients, patients with diabetes and immunological challenged patients. We have unique visulisations and a game about a patient case. Advanced readings will invite you to look at the different subjects in more depth. At the end of the module there are interviews about a patient with diabetes and the transplant recipient and donor to illustrate the impact of life. You can discuss patient cases on the forum together with your peers. In the honors lesson you can apply knowledge about more in depth immunological, surgical and metabolic challenges and living kidney donation. Let’s start and we hope you will enjoy this module.


14 videos, 6 readings expand

1. Video: Short Introduction
2. Video: Immunological Challenged Patient: ABO Incompatible Transplants
3. Video: Immunological Challenged Patient: Highly Sensitized Patient
4. Video: The Diabetic Patient
5. Video: The Elderly Patient
6. Video: Organ Procurement and Preservation
7. Video: Kidney Transplant Surgery
8. Video: Simultaneous Pancreas Kidney & Islet Transplantation
9. Video: A: Cases from Daily Practice: Different Choices for Different Diabetic Patients
10. Video: B: Cases from Daily Practice: Different Choices for Different Diabetic Patients
11. Reading: Serious Game: A Patient with Immunological Challenges
12. Discussion Prompt: E-tivity: Which treatment do you advise?
13. Video: Interview: Patient with Diabetes
14. Video: Interview: Transplant Recipient and Donor: Part 2
15. Reading: Glossary
16. Reading: References
17. Video: B Cell Replacement and Diabetes Type II
18. Video: Surgical Challenged Patients
19. Reading: Highly Sensitized Patients: The AM Program
20. Reading: Additional Challenged Transplant Recipients
21. Reading: Living Kidney Donation
22. Discussion Prompt: E-tivity: Do you accept this donor?

Graded: Check your knowledge
Graded: Check your knowledge

WEEK 3


Early Challenges in Transplantation



You are now familiar with the basic knowledge about challenges in transplant recipients and the surgical transplant procedures. Once the transplantation has been successful, it doesn’t mean everything is stable. What are actually the graft survival data? Which challenges do we face in the first months? How can we tackle these challenges? 3D movies about early surgical challenges and about the targets for immunosuppressives, including cell therapy, will help you to understand the concepts. In addition, we invite you to master the advanced knowledge and to give your opinion in the patient cases in the forum. There is also a serious game about a patient case. Can you solve the challenges? And can you think of a scenario for the game and help us with building? We will make a game of the best scenario, which will be incorporated in the course. In the honors lesson you can learn in more detail about immunological concepts, including the complement system. A patient case will help to show you the importance of this knowledge. Good luck with this module and happy learning!


12 videos, 9 readings expand

1. Video: Introduction & Overview of Early Challenges in Transplantation
2. Video: Surgical Challenges in the Early Period
3. Video: Ischemia Reperfusion Injury
4. Video: Cellular Rejection
5. Video: Antibody Mediated Rejection
6. Video: Immune Suppression
7. Video: Novel Therapeutics: Cell Therapy after Transplantation
8. Discussion Prompt: Advanced e-tivity - MSC therapy in the transplant recipient
9. Video: Cases from Daily Practice A - Patient Cases with Early Challenges
10. Video: Cases from Daily Practice B - Patient Cases with Early Challenges
11. Reading: Serious Game: Interactive Patient Case
12. Peer Review: Design the next game
13. Video: Interview Transplant Recipient & Donor: Part 3
14. Reading: Optional - Immunesuppressive Regimens and Toxicity Profiles
15. Reading: Biomarkers
16. Reading: Therapeutic drug monitoring of immunosuppressive drugs
17. Discussion Prompt: Etivity: Personalized dosing: what is your advice
18. Discussion Prompt: Etivity: What is your therapeutic advice?
19. Reading: Glossary
20. Reading: References
21. Video: The Complement System and Transplantation
22. Video: Cases from Daily Practice: Patient Case with an Early Challenge
23. Reading: A closer Look at Antibody Mediated Rejection
24. Reading: Innate Immunity and Impact on Transplantation
25. Reading: Molecular Insights into Cellular Rejection
26. Discussion Prompt: Advanced e-tivity - Which cytokine is target of the next drug?

Graded: Check your knowledge
Graded: Check your knowledge

WEEK 4


Late Challenges in Transplantation



Now you’ve learned about the challenges in the early period after transplantation. But what about the late period? What is the long term patient and allograft survival? Have we improved in the last decades? What are the main causes for morbidity and mortality? And can we reach tolerance in the future? We invite you to give your opinion in the patient cases and to discuss it on the forum. There are also advanced readings to look at additional subjects, including recurrence of the kidney disease after transplantation, the organization of dermatological care for the transplant recipient and the role of the patient himself in the whole process. The interview about tolerance gives you insight why pregnancy is of interest to understand the concept of tolerance and which steps have been made from lab research to a clinical protocol. In the honors lesson late challenges will be discussed in more detail, with a focus on infections, recurrence of the kidney disease after transplantation and tolerance. Have fun and good luck with this last module.


12 videos, 5 readings, 3 practice quizzes expand

1. Video: Introduction & Overview of Late Challenges in Transplantation
2. Video: Infections: Overview and CMV infection
3. Video: Infections: BK and EBV infection
4. Video: Malignancies
5. Reading: Pneumocystis jirovecii
6. Discussion Prompt: E-tivity - How can we prevent Pneumocystis Jirovecii Pneumoniae?
7. Video: Late Challenges after Pancreas and Islet Transplantation
8. Video: Post Transplant Diabetes Mellitus
9. Video: Cardiovascular Disease
10. Discussion Prompt: E-tivity - Why do many transplant patients suffer from obesity?
11. Video: Tolerance: Interview with Prof. Claas (LUMC) and Prof. Wood (Oxford)
12. Video: Cases from Daily Practice A - Patient Cases with Late Challenges
13. Video: Cases from Daily Practice B - Patient Cases with Late Challenges
14. Discussion Prompt: E-tivity - Can the patient himself influence allograft survival
15. Practice Quiz: Patient Case 1: Enhanced Glucose after SPK
16. Practice Quiz: Patient Case 2: Hyperglycemia after Islet Transplantation
17. Practice Quiz: Patient Case 3: A Complication after Pancreas-alone Transplantation
18. Reading: Glossary
19. Reading: References
20. Video: Recurrence of Kidney Disease after Transplantation
21. Video: Vaccination and Transplantation
22. Reading: Skin Diseases after Transplantation and Dermatological Aftercare
23. Reading: Tolerance in more Detail
24. Discussion Prompt: E-tivity: How can we reach tolerance?

Graded: Check your knowledge
Graded: Advise your Colleague: Donor Derived Infections
Graded: Check your knowledge

Final Quiz
We hope you have enjoyed all the modules. Good luck with the final quiz! If you are interested in an intensive course about transplantation go to the course resources.

Graded: Final Exam
Graded: Final Honours Exam