Advanced Neurobiology I

About this course: Hello everyone! Welcome to advanced neurobiology! Neuroscience is a wonderful branch of science on how our brain perceives the external world, how our brain thinks, how our brain responds to the outside of the world, and how during disease or aging the neuronal connections deteriorate. We’re trying to understand the molecular, cellular nature and the circuitry arrangement of how nervous system works. Through this course, you'll have a comprehensive understanding of basic neuroanatomy, electral signal transduction, movement and several diseases in the nervous system. This advanced neurobiology course is composed of 2 parts (Advanced neurobiology I and Advanced neurobiology II, and the latter will be online later). They are related to each other on the content but separate on scoring and certification, so you can choose either or both. It’s recommended that you take them sequentially and it’s great if you’ve already acquired a basic understanding of biology. Thank you for joining us!

Created by:  Peking University

• Taught by:  Yan Zhang, Professor

  School of Life Sciences, Peking University

• Taught by:  Yulong Li, Research Fellow

  School of Life Sciences, Peking University

Level Intermediate Language English How To Pass Pass all graded assignments to complete the course. User Ratings 3.7 stars Average User Rating 3.7See what learners said Coursework

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Peking University Peking University is determined to make its education openly accessible to students in China and around the world. With over 3000 faculty members, Peking University offers excellence in teaching and learning. Founded in 1898, Peking University (PKU) was the first national comprehensive university in China. For the past 115 years, with its hundreds of thousands of outstanding alumni, Peking University has made prominent contributions in the humanities and sciences to further China's prosperity and progress.

Syllabus


WEEK 1


Anatomy of the Nervous System
Let's start with a basic introduction of neuroanatomy.


32 videos, 1 reading expand

1. Video: Welcome to Advanced Neurobilology!
2. Reading: Slides are available both in video and adneuro@outlook.com
3. Video: 1.1.1 Terminology
4. Video: 1.1.2 Central nervous system and blood brain barrier
5. Video: 1.1.3 Meninges
6. Video: 1.1.4 Telencephalon
7. Video: 1.1.5 The localization and globalization theory
8. Video: 1.1.6 White matter
9. Video: 1.1.7 Internal structures
10. Video: 1.1.8 Hippocampus and LTP
11. Video: 1.1.9 Cerebellum
12. Video: 1.2.1 Brain stem
13. Video: 1.2.2 Cranial nerves
14. Video: 1.2.3 Ascending and descending tracts and reticular formation
15. Video: 1.2.4 Pons
16. Video: 1.2.5 Reflex and reflex arc
17. Video: 1.2.6 Concepts in the CNS and PNS
18. Video: 1.2.7 Spinal cord
19. Video: 1.2.8 The visceral nervous system
20. Video: 1.2.9 Several pathways of the nervous system
21. Video: 1 神经科学引言
22. Video: 2 神经科学与人类健康和医药工业
23. Video: 3 神经科学的启蒙时代
24. Video: 4 神经科学的问题、方法、层次
25. Video: 5 脑的功能分区：颅相学与Broca’s area
26. Video: 6 脑的功能分区：皮层的分区
27. Video: 7 脑的功能分区：两半球的差别
28. Video: 8 PET和fMRI
29. Video: 9 外周神经系统
30. Video: 10 神经元学说和神经元极性
31. Video: 11 神经环路
32. Video: 12 神经信息传递：动作电位
33. Video: 13 神经信息传递-化学传递

Graded: Quiz 1.1
Graded: Quiz 1.2

WEEK 2


Morphology of the neuronal cell & Cellular and Molecular Biology of the Neuron
Let's learn more about the basic unit of the nervous system: the neuron.


19 videos expand

1. Video: 2.1 Reductionism and hypothesis
2. Video: 2.2 Morphology of the neuron
3. Video: 2.3 Visualization of neurons and the neuron doctrine
4. Video: 2.4 The story of the fluorescent proteins
5. Video: 2.5 Stories of the Nobel prize
6. Video: 2.6 Organic fluorescent probes
7. Video: 2.7 Proteins specifically expressed in neurons and "brainbow" technique
8. Video: 2.8 Microscopy techniques I
9. Video: 2.9 Microscopy techniques II
10. Video: 2.10 The electron microscope
11. Video: 2.11 Glia and myelination
12. Video: 2.12 Research: AIS and Ankyrin G
13. Video: 3.1.1 A overview of neurons
14. Video: 3.1.2 Real life situation: Aβ in Alzheimer’s disease
15. Video: 3.1.3 Organelles and cytoskeleton in neurons
16. Video: 3.1.4 Research: induction of the tunneling nanotube
17. Video: 3.1.5 Defects in myelination and related diseases
18. Video: 3.1.6 Synthesis and trafficking of neuronal proteins I
19. Video: 3.1.7 Synthesis and trafficking of neuronal proteins II

Graded: Quiz 2
Graded: Quiz 3.1

WEEK 3


Cellular and Molecular Biology of the Neuron
Let‘s continue with the neuron.


16 videos expand

1. Video: 3.2.1 Cellular information transfer
2. Video: 3.2.2 Signaling molecules
3. Video: 3.2.3 Neurotransmitters and receptors
4. Video: 3.2.4 The synapse
5. Video: 3.2.5 Types of receptors
6. Video: 3.2.6 Crosstalk of cellular signal transduction pathways
7. Video: 3.2.7 The LTP
8. Video: 3.2.8 The molecular mechanism of learning and memory
9. Video: 3.2.9 Glia in a synapse
10. Video: 3.3.1 Alzheimer’s disease: introduction and myths
11. Video: 3.3.2 Alzheimer’s disease: pathology
12. Video: 3.3.3 Parkinson’s disease: introduction
13. Video: 3.3.4 Parkinson’s disease: symptoms and prognosis
14. Video: 3.3.5 Parkinson’s disease: pathology
15. Video: 3.3.6 Parkinson’s disease: treatment
16. Video: 3.3.7 Prion diseases

Graded: Quiz 3.2
Graded: Quiz 3.3

WEEK 4


Signaling within neurons & Ion channels and membrane potentials
Let's switch to the electrical properties of the neuron.


30 videos, 2 readings expand

1. Video: 4.1 Overview
2. Video: 4.2 The resting potential
3. Video: 4.3 The resting potential and the Nernst equation
4. Video: 4.4 The Nernst Equation
5. Video: 4.5 Biological and electrical proporties of neurons I
6. Video: 4.6 Biological and electrical proporties of neurons II
7. Video: 4.7 Biological and electrical proporties of neurons III.
8. Video: 5.1 Ion channels and membrane potentials I
9. Video: 5.2 Ion channels and membrane potentials II
10. Video: 5.3 Ion channels and membrane potentials III
11. Video: 5.4 Ion channels and membrane potentials IV
12. Video: 5.5 Ion channels and membrane potentials V
13. Video: 5.6 Ion channels and membrane potentials VI
14. Video: 5.7 Ion channels and membrane potentials VII
15. Video: 5.8 Ion channels and membrane potentials VIII
16. Reading: Lab page of Dr. Kang Shen
17. Video: Kang Shen - 1
18. Video: Kang Shen - 2
19. Video: Kang Shen -3
20. Video: Kang Shen - 4
21. Video: Kang Shen - 5
22. Video: Kang Shen - 6
23. Video: Kang Shen - 7
24. Video: Kang Shen - 8
25. Reading: Lab page of Dr. Liqun Luo
26. Video: Liqun Luo - 1
27. Video: Liqun Luo - 2
28. Video: Liqun Luo - 3
29. Video: Liqun Luo - 4
30. Video: Liqun Luo - 5
31. Video: Liqun Luo - 6
32. Video: Liqun Luo - 7

Graded: Quiz 4
Graded: Quiz 5

WEEK 5


Ion channels, membrane potential and synaptic transmission
Let's continue with the ion channels, membrane potential and synaptic transmission.


8 videos expand

1. Video: 6.1 Voltage sensing
2. Video: 6.2 The Na+ gating current
3. Video: 6.3 Inactivation gates
4. Video: 6.4 Ion channel, membrane potential and synaptic transmission I
5. Video: 6.5 Ion channel, membrane potential and synaptic transmission II
6. Video: 6.6 Ion channel, membrane potential and synaptic transmission III
7. Video: 6.7 Ion channel, membrane potential and synaptic transmission IV
8. Video: 6.8 Ion channel, membrane potential and synaptic transmission V

Graded: Quiz 6

WEEK 6


Neurotransmitter release
Let's learn more about the neurotransmitter release.


14 videos expand

1. Video: 7.1 How does Ca2+ control neurotransmitter release I
2. Video: 7.2 How does Ca2+ control neurotransmitter release II
3. Video: 7.3 How does Ca2+ control neurotransmitter release III
4. Video: 7.4 How does Ca2+ control neurotransmitter release IV
5. Video: 7.5 Molecular mechanism involved in neurotransmetter release I
6. Video: 7.6 Molecular mechanism involved in neurotransmetter release II
7. Video: 7.7 Molecular mechanism involved in neurotransmetter release III
8. Video: 7.8 Molecular mechanism involved in neurotransmetter release IV
9. Video: 7.9 Molecular mechanism involved in neurotransmetter release V
10. Video: 7.10 Molecular mechanism involved in neurotransmetter release VI
11. Video: 7.11 Molecular mechanism involved in neurotransmetter release VII
12. Video: 7.12 Molecular mechanism involved in neurotransmetter release VIII
13. Video: 7.13 Molecular mechanism involved in neurotransmetter release IX
14. Video: 7.14 Molecular mechanism involved in neurotransmetter release X

Graded: Quiz 7

WEEK 7


Synaptic transmission & Synapitic plasticity
Let's continue with synaptic transmission and synapitic plasticity.


12 videos expand

1. Video: 8.1 Synaptic trasmission I
2. Video: 8.2 Synaptic trasmission II
3. Video: 8.3 Synaptic trasmission III
4. Video: 8.4 Synaptic transmission IV
5. Video: 8.5 Synaptic trasmission V
6. Video: 8.6 Synaptic trasmission VI
7. Video: 9.1 Synapitic plasticity I
8. Video: 9.2 Synapitic plasticity II
9. Video: 9.3 Synapitic plasticity III
10. Video: 9.4 Synapitic plasticity IV
11. Video: 9.5 Synapitic plasticity V
12. Video: 9.6 Synapitic plasticity VI

Graded: Quiz 8
Graded: Quiz 9

WEEK 8


Techniques in neuroscience
Let's learn some prevalent techniques in neuroscience.


6 videos expand

1. Video: 10.1 Observation and perturbation
2. Video: 10.2 Animal models in neurological research
3. Video: 10.3 Genetic and molecular techniques
4. Video: 10.4 Anatomical techniques
5. Video: 10.5 Mapping synaptic connections
6. Video: 10.6 Patch recording and optical imaging

Graded: Quiz 10